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Scientists also refer to TRPV1 as a "vanilloid receptor," named for its vanilla flavor. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; It also helps to unclog blood vessels. Historically, vanilla has been used as a popular cure for headaches. The CBD is an "agonist" of TRPV1 or stimulant. This is probably one of the reasons why Cannabis rich in CBD is an effective treatment for neuropathic pain. Capsaicin, the spicy compound in chili peppers - activates the TRVP1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV1 agonist.

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