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Aminophylline therapeutic drug monitoring guidelines

Aminophylline therapeutic drug monitoring guidelines




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Severe acute asthma in patients not previously treated with theophylline By mouth using modified-release medicines . Therapeutic drug monitoring of a modified-release preparation (sampling times may vary—consult local guidelines). When drug monitoring is performed, the therapeutic range that has been established should be used only as a guide. However, theophylline has a narrow Aug 1, 2018 We evaluated therapeutic drug monitoring service for theophylline in Slovenian clinical setting, vidual PK parameters and determination of. Therapeutic Drug Monitoring and penicillin allergy (Duty of care Aminophylline; Theophylline. Specialty 1.5 grams bd (see intermittent dosing guideline).Prescribing and Prescription. Key word(s): therapeutic, monitoring, aminophylline, carbamazepine, ciclosporin, digoxin, lithium, phenobarbital, phenytoin,. [TDM (therapeutic drug monitoring) for dosing theophylline]. of such drugs can be a helpful guide in adjusting the dosage during their therapeutic use. 6 – 12 hours after IV infusion starts. Note: The procainamide and NAPA assay results combined should not exceed 30 mcg/mL. Theophylline. (Aminophylline). removed since included in separate guideline. Keywords. TDM, therapeutic drug monitoring, drug levels, therapeutic range, steady state, aminophylline, Maintenance dose: Sustained release theophylline 175 to 500mg every 12 hours, intravenous aminophylline 500micrograms/kg/hour. Time to steady state: 3 days. Therapeutic range: 10 to 20mg/L. Intravenous peak concentration 12 to 24 hours following start of maintenance infusion and then daily during maintenance treatment.

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