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Causes, molecular mechanisms, prevention and treatment of cancer. The tumor suppressor protein p53 is a transcription factor that has been called the "guardian of the genome". When DNA damage has occurred, p53 induces the p21 protein to bind with (and inactivate) cdk2, thereby preventing transition from G 1 phase to S phase until DNA repair occurs (or causing apoptosis by enhanced if effective ... DNA Repair of Cancer Stem Cells buy DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.. Mismatch repair is strand-specific. During DNA synthesis the newly synthesised (daughter) strand will commonly include errors. 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