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Targeted cancer therapies are drugs or other substances that block the growth and spread of
cancer by interfering with specific
molecules ("molecular
targets") that are involved in the growth, progression, and spread of
cancer.
Targeted cancer therapies are sometimes called "molecularly targeted drugs," "molecularly targeted therapies," "precision medicines," or similar names. Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important
cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as well as tumor resistance
therapy.
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targets glossary & taxonomy Evolving Terminologies for Emerging Technologies Comments? Questions? Revisions? Mary Chitty MSLS mchitty@healthtech.com Last revised November 20, 2018
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Notch signaling pathway is a highly conserved cell
signaling system present in most multicellular organisms. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, … The TGFβ
signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response.
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signaling was influenced by research on oncogenic (
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cancer Supramolecule provides a double whammy to knock out
cancer's 'eat-me-not'
signaling…
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