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The concept of “oxidative stress” The term “oxidative stress” began to be used frequently in the 1970s, but its conceptual origins can be traced back to the 1950s to researchers pondering the toxic effects of ionizing radiation, free radicals, and the similar toxic effects of molecular oxygen (Gerschman et al., 1954), and the potential contribution of such processes ... The Final Problem Pretty Sacrifices 4 Heart Failure: Classifications Heart Failure Systolic vs. Diastolic High vs. Low Output Right vs. Left Sided Acute vs. Chronic Cardiac vs. Non-cardiac Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis. Therefore, oxidative stress can also be viewed as an imbalance between the prooxidants and antioxidants in the body. 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