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extracellular matrix (ECM) is a three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support of surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion ... The mammalian retina provides an excellent opportunity to study glia–neuron
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Fibronectin is a high-
molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.
Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate
proteoglycans (e.g. syndecans)..
Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a ...
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Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the
heparan sulfate proteoglycans related to protein
interactions leading to cell signaling.
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Invasion - Issue 1 - Book 1 - The Alien Alliance Hyaluronan (HA; hyaluronic acid) is composed of alternating residues of β-D-(1→3) glucuronic acid (GlcA) and β-D-(1→4)-N-acetylglucosamine (GlcNAc) (see Figure 2).Unlike the other
glycosaminoglycans, hyaluronan does not attach to proteins to form
proteoglycans.
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