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When to request an ANA. While ANAs are associated with a number of autoimmune conditions, they are most useful in the diagnosis and classification of rheumatic diseases (Table 1).Therefore, it is in patients presenting with clinical symptoms or other laboratory results suggesting a high pre-test probability of rheumatic disease that the ANA test should be considered. The Need to Know 1. Introduction. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the loss of tolerance to nucleic acids and their binding proteins. 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Active recruiting A Collection of Thoughts and Poetry Unless you become like this child INTRODUCTION. Systemic sclerosis (SSc) is a multisystem, fibrosing disorder in which vasculopathy, autoimmunity, and inflammation lead to diverse life-altering and life-threatening clinical manifestations ().SSc has the highest degree of morbidity and mortality of the rheumatic diseases with a 10-year mortality rate of 23 to 45% (2, 3).The female predominance is about 4:1, and the usual age of ... A unique medical search engine understands medical concept, medical terminology and diseases. MWSearch provides drill down searches and queries to other search engines to find medical and health information on the web, medical and health news, products and serives. 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