
Over the past decade, our understanding of
cancer immunotherapy has evolved from assessing peripheral responses in the blood to monitoring changes in the tumour microenvironment.
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cancer immunity, such as tumor antigenicity, T cell trafficking, or T cell infiltration into tumors, which provides a rationale for combining them with checkpoint inhibitors or other
cancer immunotherapies that may lead to synergistic efficacy.
Cancer immunotherapy has become highly successful against an array of distinct hematological and solid metastatic malignancies (1–6).Administration of immune checkpoint inhibitors (ICIs) unleashes T lymphocyte–mediated immune responses by suppressing the interaction of T cell inhibitory receptors with their cognate ligands on tumor or stromal cells ().
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cancer, improving on the system's natural ability to fight
cancer. It is an application of the fundamental research of
cancer immunology and a growing subspecialty of oncology.It exploits the fact that
cancer cells often have tumor antigens, molecules on their surface that can be ...
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Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not kept pace.
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